Thank you for joining us today! If anyone has questions throughout the event you can drop them in the chat or message "ACS Publications Events" directly

Please add questions to the chat.

Thank you for the excellent talk, Candace! This is such an awesome application with NMR. With the long term traumatic brain injuries, are there still residual differences in temperature when enough time has passed to heal, but the patient it still left with permanently damaged tissue? It seems like such a nice way to capture residual damage if it remained. Thank you also for sharing what worked and didn’t for your lab with DEI, it was incredibly valuable.

thank you for a nice talk

Thankyou for a super talk Candace and for being so upfront with DEI! I wanted to know, are there imaging probes that can be administered to functionally report on brain injury by chemically binding or reacting in damaged areas in any useful way? or are we kind of “stuck” with imaging endogenous species?

The fact that change in chemical shift difference between water and a particular metabolite gives us a idea of temperature changes in brain, will it not be affected by the fact that water and other metabolites do have interactions among themselves?

Very nice talk on MRS, so I would like to ask in a model of TBI, does the brain tissue switches to anaerobic respiration to produce lactate to cope up with injury impact?

Really enjoyed this talk. Thank you, Candace!

Thank you for great talk. Does have the PLD enzymes some other catalytic activity e.g. exonuclease? Is it possible that the trasnphosphatidylation can be linked to Alzheimer disease? Thank you!

Fantastic talk, Jeremy!! Are there lipid moving enzymes that the IMPACT method be applied to? It seems like a great way to learn about the kinetics of lipid transport and localization throughout the cell.

(Other than PLD*)

Great talk, do you think PLD could be having role in cell morphology transitions?

Very cool talk and research program. Thank you, Jeremy!

Excellent talk, thank you!

Wonderful talk, Oliver!

Can you expand on how different the probe is for the Trx enzyme vs. its regular substrate? Was it also a cyclic disulfide (I may have missed it).

Thank you, Oliver!! Excellent talk!

Please put questions in the chat.

Does this probe react with sugars or oligosaccharides to generate fluorescence?

Great talk, Ozlem! It’s wonderful that you can get so many students involved. I know you didn’t talk about this, but have you considered integrating this research into some of the courses you are teaching? I suspect that would increase access to even more students and benefit your research too.

Great talk, Ozlem! So wonderful to see what you are able to do with your undergraduate students! It seems that some of your probes are similar in structure to iron chelators/pro-chelators used to study/mitigate metal-promoted oxidative stress. Do you think your probes might alter the local iron concentration?

Thank you to Candace, Jeremy, Oliver, and Ozlem for fantastic talks - so much exciting research!!!

Thank you! :)

Now we’ll start the networking break!You will now be automatically sorted into 1 of 4 breakout rooms named after each speaker: Candace Fleischer, Jeremy Baskin, Oliver Thorn-Seshold, and Ozlem Dilek.If you have any troubles, please stay or return to the main lobby and send a note in the chat!

Message here if you need to enter another room

Jeremy room please

https://connect.acspubs.org/ChemBio_SummerSeries