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Hello. Good morning to all of you from India. Here is Dr. Ranjit Kumar, Department of Chemistry, Faculty of Science, Dayalbagh Educational Institute (Deemed University), Dayalbagh, Agra, India. E-mail: email@example.com
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Fantastic talk and awesome impact with the CURE!! In your random mutagenesis experiments, do you see that for all of the sites you identify as being critical, the WT amino acid needs to be strictly conserved, or were there some sites where a small group of amino acids were still permissible?
Awesome talk, Katie! Very cool research program. I have a question about your CUREs: how involved are students in designing the lab protocols for their lab work? Did this vary between your two iterations? I’m wondering how much agency over experimental design leads to building confidence in skills and explaining complex ideas. (And sidenote: I’d love to explore ways to connect our CUREs across campuses by having some shared assignments/share-outs to connect our students).
Awesome talk! it was very interesting. How much spatial resolution do you think you could achieve with your method and just out of curiosity, would you need a whole heart to implement this method?
would you be able to do time point studies?
I must leave now. It was fantastic! Thank you everybody!
Beautiful work! Do you observe that the probe molecules themselves are modified by the BSH enzymes that they are binding to during the assay?
Very nice and informative talk.
Nice work. Do all BSH enzymes use cysteine as nucleophile in the active site or would other reactive electrophiles than AOMK also be appropriate?
Very cool approach. Could you use your BSH tagging + fluorophore within tissue/luminal samples, to assess how activity changes spatially or within complex communities in situ?
Hi Tom, nice talk. Are individual differences for sensitivity to campy then related to/caused by microbiome differences? And could I try some of your probes to check my microbiome to see if I can safely eat my sous-vide cooked chicken? Q2: why did you use the biotin-cyclooctyne and not a fluorophore?
Very cool research! Are there similarities between the bacterial Leg biosynthetic pathway and the human sialic acid biosynthetic pathway?
OK, I wondered if the cell permeability of fluorophore-cyclooctyne could lead to intracellular thiol-yne reaction and additional background